Open Protocols

Protocol Name	Investigatory Role	Biomarkers	Data Collections
A Urine Exosome Gene Expression Panel Distinguishes between Indolent and Aggressive Prostate Cancers at Biopsy	Coordinating	0	0
Biomarkers for Early Detection of Aggressive Prostate Cancer	Involved	7	0
Molecular profiling of radical prostatectomy tissue from patients with no sign of progression identifies independent predictors of recurrence	Leading	0	0
Prostate Active Surveillance Study	Involved	2	0
Prostate-MRI	Involved	0	1
Proteomic Tissue-Based Classifier for Early Prediction of Prostate Cancer Progression	Coordinating	0	0

Closed Protocols

Protocol Name	Investigatory Role	Biomarkers	Data Collections
SELDI Phase I: Assay Validation-Prostate	Involved	1	1
SELDI Validation Study Phase II	Involved	1	1

Publications

Publication Name	PubMed ID	Journal
A Germline Variant at 8q24 Contributes to Familial Clustering of Prostate Cancer in Men of African Ancestry.	32409115	Eur Urol
A novel genomic alteration of LSAMP associates with aggressive prostate cancer in African American men.	26844274	EBioMedicine
A Rich Array of Prostate Cancer Molecular Biomarkers: Opportunities and Challenges.	31013716	Int J Mol Sci
A Urine Exosome Gene Expression Panel Distinguishes between Indolent and Aggressive Prostate Cancers at Biopsy.	32945736	J Urol
African-specific improvement of a polygenic hazard score for age at diagnosis of prostate cancer.	32930425	Int J Cancer
Analysis of <i>PMEPA1</i> Isoforms (<i>a</i> and <i>b</i>) as Selective Inhibitors of Androgen and TGF-β Signaling Reveals Distinct Biological and Prognostic Features in Prostate Cancer.	31842254	Cancers (Basel)
Analytical platform evaluation for quantification of ERG in prostate cancer using protein and mRNA detection methods.	25889691	J Transl Med
Association of germline genetic variants with <i>TMPRSS2-ERG</i> fusion status in prostate cancer.	32341752	Oncotarget
Autoantibodies against oncogenic ERG protein in prostate cancer: potential use in diagnosis and prognosis in a panel with C-MYC, AMACR and HERV-K Gag.	28191285	Genes Cancer
Clinical potential of the ERG oncoprotein in prostate cancer.	22331093	Nat Rev Urol
Contemporary Management of Hemorrhage After Minimally Invasive Radical Prostatectomy.	31034916	Urology
Defining the index lesion for potential salvage partial or hemi-gland ablation after radiation therapy for localized prostate cancer.	33583697	Urol Oncol
Differences in frequency of ERG oncoprotein expression between index tumors of Caucasian and African American patients with prostate cancer.	22950997	Urology
Electronic Rapid Fitness Assessment Identifies Factors Associated with Adverse Early Postoperative Outcomes following Radical Cystectomy. Reply.	33591802	J Urol
ERG monoclonal antibody in the diagnosis and biological stratification of prostate cancer: delineation of minimal epitope, critical residues for binding, and molecular basis of specificity.	25170998	Monoclon Antib Immunodiagn Immunother
ERG oncoprotein expression in prostate carcinoma patients of different ethnicities.	25469265	Mol Clin Oncol
ERG oncoprotein inhibits ANXA2 expression and function in prostate cancer.	25344575	Mol Cancer Res
ERG protein expression and genomic rearrangement status in primary and metastatic prostate cancer--a comparative study of two monoclonal antibodies.	22231490	Prostate Cancer Prostatic Dis
Ethnicity and ERG frequency in prostate cancer.	28872154	Nat Rev Urol
Evaluation of serum protein profiling by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry for the detection of prostate cancer: I. Assessment of platform reproducibility.	15613711	Clin Chem
Evolution in technique of robotic intracorporeal continent catheterizable pouch after cystectomy.	31893282	Urol Video J
Functional antagonism of TMPRSS2-ERG splice variants in prostate cancer.	25221645	Genes Cancer
Genetic and molecular differences in prostate carcinogenesis between African American and Caucasian American men.	23892597	Int J Mol Sci
Impact of caregiver overnight stay on postoperative outcomes.	31940152	Int J Health Care Qual Assur
Increased association of the ERG oncoprotein expression in advanced stages of prostate cancer in Filipinos.	24909781	Prostate
Increased frequency of germline BRCA2 mutations associates with prostate cancer metastasis in a racially diverse patient population.	30542053	Prostate Cancer Prostatic Dis
Isolated urethral metastasis from appendiceal mucinous adenocarcinoma.	32526660	Clin Imaging
Low Frequency of the ERG Oncogene Alterations in Prostate Cancer Patients from India.	23901346	J Cancer
Molecular profiling of radical prostatectomy tissue from patients with no sign of progression identifies <i>ERG</i> as the strongest independent predictor of recurrence.	31741711	Oncotarget
Multi-omic serum biomarkers for prognosis of disease progression in prostate cancer.	31910880	J Transl Med
Patient-reported pain, discomfort, and anxiety during magnetic resonance imaging-targeted prostate biopsy.	31793867	Can Urol Assoc J
Performance of African-ancestry-specific polygenic hazard score varies according to local ancestry in 8q24.	34127801	Prostate Cancer Prostatic Dis
Philadelphia Prostate Cancer Genetic Consensus Conference 2019 and implications for military medicine.	34129457	Can J Urol
Predicting Prostate Cancer Progression as a Function of ETS-related Gene Status, Race, and Obesity in a Longitudinal Patient Cohort.	28753864	Eur Urol Focus
Predominance of ERG-negative high-grade prostate cancers in African American men.	25279185	Mol Clin Oncol
Prognostic features of Annexin A2 expression in prostate cancer.	32967771	Pathology
Proteomic Tissue-Based Classifier for Early Prediction of Prostate Cancer Progression.	32429558	Cancers (Basel)
Publisher Correction: Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction.	33473200	Nat Genet
Reply to Benjamin S. Simpson, Lina M. Carmona Echeverria, Joseph M. Norris, Hashim U. Ahmed, Caroline M. Moore, and Hayley C. Whitaker's Letter to the Editor re: Gregory T. Chesnut, Emily A. Vertosick, Nicole Benfante, et al. Role of Changes in Magne	32522388	Eur Urol
Reply to Jianhui Du, Yueguang Liu, and Weigang Yan's Letter to the Editor re: Gregory T. Chesnut, Emily A. Vertosick, Nicole Benfante, et al. Role of Changes in Magnetic Resonance Imaging or Clinical Stage in Evaluation of Disease Progression for Men	32386781	Eur Urol
Role of Changes in Magnetic Resonance Imaging or Clinical Stage in Evaluation of Disease Progression for Men with Prostate Cancer on Active Surveillance.	31874726	Eur Urol
SELDI-TOF MS whole serum proteomic profiling with IMAC surface does not reliably detect prostate cancer.	18024530	Clin Chem
Serum Small RNA Sequencing and miR-375 Assay Do Not Identify the Presence of Pure Teratoma at Postchemotherapy Retroperitoneal Lymph Node Dissection.	33997822	Eur Urol Open Sci
Standardizing Opioid Prescriptions to Patients After Ambulatory Oncologic Surgery Reduces Overprescription.	32499083	Jt Comm J Qual Patient Saf
Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction.	33398198	Nat Genet

Interests

No interests found at the present moment.

To update protocols, publications, biomarkers, or science data, please contact the Data Management and Coordinating Center.

Site

Center for Prostate Disease Research Uniformed Services University of the Health Sciences and the Walter Reed National Military Medical Center

Degree(s)

M.D.

Email

gregory.t.chesnut.mil@health.mil

Person ID

4532

EDRN Title

EDRN Principal Investigator

Note

To update contact information, please visit the Data Management and Coordinating Center .