Open Protocols

Protocol Name	Investigatory Role	Biomarkers	Data Collections
Biomarkers of Risk for Colorectal Neoplasia (Team Project #2)	Involved	0	0
Using the methylome to identify aggressive Barrett’s esophagus	Leading	0	0

Closed Protocols

This person has no closed protocols at the present moment.

Publications

Publication Name	PubMed ID	Journal
Aberrant DNA methylation occurs in colon neoplasms arising in the azoxymethane colon cancer model.	19777566	Mol Carcinog
Aberrantly methylated CDKN2A, MGMT, and MLH1 in colon polyps and in fecal DNA from patients with colorectal polyps.	15709190	Clin Cancer Res
Aberrantly methylated PKP1 in the progression of Barrett's esophagus to esophageal adenocarcinoma.	22170739	Genes Chromosomes Cancer
Assessment of familiality, obesity, and other risk factors for early age of cancer diagnosis in adenocarcinomas of the esophagus and gastroesophageal junction.	19491834	Am J Gastroenterol
CIMP and colon cancer gets more complicated.	17938428	Gut
Colorectal cancer molecular biology moves into clinical practice.	20921207	Gut
Colorectal endoscopy, advanced adenomas, and sessile serrated polyps: implications for proximal colon cancer.	22688851	Am J Gastroenterol
Cost-Effectiveness of Liquid Biopsy for Colorectal Cancer Screening in Patients Who Are Unscreened.	37971743
CpG island methylation of genes accumulates during the adenoma progression step of the multistep pathogenesis of colorectal cancer.	16708352	Genes Chromosomes Cancer
DNA alkylation and DNA methylation: cooperating mechanisms driving the formation of colorectal adenomas and adenocarcinomas?	17339242	Gut
DNA methylation and gene expression profiling of ewing sarcoma primary tumors reveal genes that are potential targets of epigenetic inactivation.	23024594	Sarcoma
DNA methylation profiling across the spectrum of HPV-associated anal squamous neoplasia.	23226306	PLoS One
DNA methylation profiling in Barrett's esophagus and esophageal adenocarcinoma reveals unique methylation signatures and molecular subclasses.	22139570	Epigenetics
Epigenetic biomarkers in esophageal cancer.	22406828	Cancer Lett
Epigenetic silencing of the intronic microRNA hsa-miR-342 and its host gene EVL in colorectal cancer.	18264139	Oncogene
Epigenetics and colorectal cancer.	22009203	Nat Rev Gastroenterol Hepatol
Epigenomic analysis of aberrantly methylated genes in colorectal cancer identifies genes commonly affected by epigenetic alterations.	21298349	Ann Surg Oncol
Evidence for the role of aberrant DNA methylation in the pathogenesis of Lynch syndrome adenomas.	17278092	Int J Cancer
Genomic aberrations occurring in subsets of serrated colorectal lesions but not conventional adenomas.	23539450	Cancer Res
Genomic and epigenetic instability in colorectal cancer pathogenesis.	18773902	Gastroenterology
Genomic instability and colorectal cancer.	17024019	Curr Opin Gastroenterol
Inactivation of TGF-β signaling and loss of PTEN cooperate to induce colon cancer in vivo.	23604118	Oncogene
Insights into the role of DNA methylation in disease through the use of mouse models.	20427558	Dis Model Mech
Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas.	17349581	Cancer Cell
Linking epidemiology to epigenomics--where are we today?	21149325	Cancer Prev Res (Phila)
Making the case for DCC and UNC5C as tumor-suppressor genes in the colon.	18054576	Gastroenterology
Mapping the core senescence phenotype of primary human colon fibroblasts.	38385965
Mutational inactivation of TGFBR2 in microsatellite unstable colon cancer arises from the cooperation of genomic instability and the clonal outgrowth of transforming growth factor beta resistant cells.	17985359	Genes Chromosomes Cancer
Natural History of Colorectal Polyps Undergoing Longitudinal in Vivo CT Colonography Surveillance.	38289210
Patients With Esophageal Adenocarcinoma With Prior Gastroesophageal Reflux Disease Symptoms Are Similar to Those Without Gastroesophageal Reflux Disease: A Cross-Sectional Study.	37975600
Proliferation and Cdk4 expression in microsatellite unstable colon cancers with TGFBR2 mutations.	16108056	Int J Cancer
Promoter methylation status of the MGMT, hMLH1, and CDKN2A/p16 genes in non-neoplastic mucosa of patients with and without colorectal adenomas.	16820927	Oncol Rep
Quality assessment and correlation of microsatellite instability and immunohistochemical markers among population- and clinic-based colorectal tumors results from the Colon Cancer Family Registry.	21497289	J Mol Diagn
RET is a potential tumor suppressor gene in colorectal cancer.	22751117	Oncogene
TGF-beta has paradoxical and context dependent effects on proliferation and anoikis in human colorectal cancer cell lines.	18651288	Growth Factors
TGF-beta receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a beta-catenin-independent pathway.	19208363	Gastroenterology
TGF-beta receptor levels regulate the specificity of signaling pathway activation and biological effects of TGF-beta.	19339207	Biochim Biophys Acta
The aberrant methylation of TSP1 suppresses TGF-beta1 activation in colorectal cancer.	18425817	Int J Cancer
The next thing in prognostic molecular markers: microRNA signatures of cancer.	20551450	Gut
Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation.	17047044	Cancer Res

Interests

colon cancer biomarkers

Methylated genes as early detection markers for colon cancer and colon adenomas.

Colorectal cancer biomarkers

Methylated genes as risk markers and early detection markers for colon adenomas and adenocarcinomas

DNA methylation

Biomarkers for GI cancer

Barretts esophagus

Prognostic biomarkers for Barretts esophagus and esophageal adenocarcinoma

To update protocols, publications, biomarkers, or science data, please contact the Data Management and Coordinating Center.

Site

Fred Hutchinson Cancer Center

Degree(s)

M.D.

Email

wgrady@fredhutch.org

Fax

206-667-2917

Person ID

1371

Note

To update contact information, please visit the Data Management and Coordinating Center .