Open Protocols

Protocol Name	Investigatory Role	Biomarkers	Data Collections
Biomarkers for early detection of pancreatic cancer	Coordinating	0	1
Pancreatic Cancer Early Detection Stem Cell Biomarkers (CA117452 Set-Aside)	Coordinating	0	1
Pre-diagnostic Pancreatic Cancer Set Aside Project	Involved	25	0
Standard Specimen Reference Set: Breast Cancer and Imaging	Involved	0	3
Validation of plasma biomarker panels for the early detection of pancreatic cancer	Involved	0	0

Closed Protocols

Protocol Name	Investigatory Role	Biomarkers	Data Collections
A Biomarker Bakeoff in Early Stage Pancreatic Cancer	Involved	11	0
BRSCW Reference Set Application: Anna Lokshin - Univ of Pitts (2008)	Leading	24	0
Pancreatic Cancer Bake Off 2	Involved	4	0
Phase II Validation of a New Panel of Biomarkers for Early Detection of Ovarian Cancer	Involved	7	0
PLCO Ovarian Phase III Validation Study	Involved	50	1
Prostate Rapid Pre-Validation Set	Involved	6	0
SPORE/EDRN/PRE-PLCO Ovarian Phase II Validation Study	Involved	55	2

Publications

Publication Name	PubMed ID	Journal
Adenosine-mediated inhibition of cytotoxic activity and cytokine production by IL-2/NKp46-activated NK cells: involvement of protein kinase A isozyme I (PKA I).	17337770	Immunol Res
Adenosine-mediated inhibition of the cytotoxic activity and cytokine production by activated natural killer cells.	16885379	Cancer Res
Assessment of 54 biomarkers for biopsy-detectable prostate cancer.	17932343	Cancer Epidemiol Biomarkers Prev
Biomarker approaches to the development of cancer screening tests: can cancer blood tests become a routine health check-up?	17547524	Future Oncol
Circulating IL-8 and anti-IL-8 autoantibody in patients with ovarian cancer.	16434085	Gynecol Oncol
Combined antiangiogenic and immune therapy of prostate cancer.	16132614	Angiogenesis
Cooperation of adenosine and prostaglandin E2 (PGE2) in amplification of cAMP-PKA signaling and immunosuppression.	18327580	Cancer Immunol Immunother
Development of multimarker panel for early detection of endometrial cancer. High diagnostic power of prolactin.	17659325	Gynecol Oncol
Differential regulation of maturation and apoptosis of human monocyte-derived dendritic cells mediated by MHC class II.	12202400	Int Immunol
Dynamic alteration of soluble serum biomarkers in healthy aging.	17689975	Cytokine
Early detection and staging of adenocarcinoma of the pancreas.	17533087	Gastroenterol Clin North Am
Early detection of head and neck cancer: development of a novel screening tool using multiplexed immunobead-based biomarker profiling.	17220337	Cancer Epidemiol Biomarkers Prev
Expression of chemokines in GVHD target organs is influenced by conditioning and genetic factors and amplified by GVHR.	16737935	Biol Blood Marrow Transplant
High-sensitivity blood-based detection of breast cancer by multi photon detection diagnostic proteomics.	16889412	J Proteome Res
IG20, a MADD splice variant, increases cell susceptibility to gamma-irradiation and induces soluble mediators that suppress tumor cell growth.	14695193	Cancer Res
IL-12 receptor-mediated upregulation of FasL in human ovarian carcinoma cells.	15382042	Int J Cancer
Inhibition of cytokine production and cytotoxic activity of human antimelanoma specific CD8+ and CD4+ T lymphocytes by adenosine-protein kinase A type I signaling.	17575165	Cancer Res
Intratumoral cytokines/chemokines/growth factors and tumor infiltrating dendritic cells: friends or enemies?	17029028	Cancer Metastasis Rev
Intravenous and isolated limb perfusion delivery of wild type and a tumor-selective replicating mutant vaccinia virus in nonhuman primates.	16409123	Hum Gene Ther
Is the monocyte chemotactic protein-1 -2518 G allele a risk factor for severe acute pancreatitis?	15880317	Clin Gastroenterol Hepatol
Loss of new chemokine CXCL14 in tumor tissue is associated with low infiltration by dendritic cells (DC), while restoration of human CXCL14 expression in tumor cells causes attraction of DC both in vitro and in vivo.	15843547	J Immunol
Low-dose paclitaxel prior to intratumoral dendritic cell vaccine modulates intratumoral cytokine network and lung cancer growth.	17875775	Clin Cancer Res
Multianalyte profiling of serum cytokines for detection of pancreatic cancer.	17192050	Cancer Biomark
Multiple biomarker panels for early detection of ovarian cancer.	17155900	Future Oncol
Multiple effects of TRAIL in human carcinoma cells: induction of apoptosis, senescence, proliferation, and cytokine production.	18313665	Exp Cell Res
Multiplex analysis of serum cytokines in melanoma patients treated with interferon-alpha2b.	17438101	Clin Cancer Res
Multiplexed immunobead-based cytokine profiling for early detection of ovarian cancer.	15824174	Cancer Epidemiol Biomarkers Prev
New tumor markers: CA125 and beyond.	16343244	Int J Gynecol Cancer
Obesity, adipokines, and prostate cancer in a prospective population-based study.	16835332	Cancer Epidemiol Biomarkers Prev
Physiological and molecular effects of Apo2L/TRAIL and cisplatin in ovarian carcinoma cell lines.	12536078	Cancer Lett
Prevention and early detection of ovarian cancer: mission impossible?	17302189	Recent Results Cancer Res
Reconstitution of galectin-3 alters glutathione content and potentiates TRAIL-induced cytotoxicity by dephosphorylation of Akt.	12878156	Exp Cell Res
Reduction of graft-versus-host disease by histone deacetylase inhibitor suberonylanilide hydroxamic acid is associated with modulation of inflammatory cytokine milieu and involves inhibition of STAT1.	16728283	Exp Hematol
Role of antiapoptotic proteins in tumor necrosis factor-related apoptosis-inducing ligand and cisplatin-augmented apoptosis.	12912965	Clin Cancer Res

Interests

Biomarkers for early cancer detection

My interests focus on the discovery of multibiomarker profiles that allow for early detection of cancer. To-date,we have identified biomarker panels with strong diagnostic power for ovarian, pancreatic, and endometrial cancers.

To update protocols, publications, biomarkers, or science data, please contact the Data Management and Coordinating Center.

Site

University of Pittsburgh Cancer Institute

Degree(s)

Ph.D.

Email

lokshina@pitt.edu

Fax

412-623-3355

Person ID

1645

EDRN Title

EDRN Associate Member

Note

To update contact information, please visit the Data Management and Coordinating Center .