Chinnaiyan, Arul M.
Open Protocols
Closed Protocols
| Protocol Name | Investigatory Role | Biomarkers | Data Collections |
|---|---|---|---|
| EDRN-WHI Pre-Clinical Colon Ca Specimens | Involved | 0 | 1 |
| PCA3 Reference Set Application: Arul Chinnaiyan (2020) | Leading | 0 | 0 |
Publications
Interests
- Cancer Genomics, Biomarkers, Proteomics, Bioinformatics
- The Chinnaiyan laboratory has focused on functional genomic, proteomic, metabolomic, and bioinformatics approaches to study cancer for the purposes of understanding tumor biology as well as to discover clinical biomarkers. He and his collaborators have characterized a number of biomarkers of prostate cancer including AMACR, EZH2, hepsin, the sarcosine metabolite, and TMPRSS2-ETS gene fusions. AMACR is being used clinically across the country in the assessment of cancer in prostate needle biopsies. The Chinnaiyan laboratory is a fertile training ground for the next generation of translational researchers having already impacted the careers of over 20 graduate students and 40 research fellows.
The landmark study thus far from Dr. Chinnaiyan’s laboratory is the discovery of TMPRSS2-ETS gene fusions in a majority of prostate cancers. This discovery was made using a bioinformatics approach on tumor gene expression data. TMPRSS2-ETS gene fusions are specific markers of prostate cancer as well as presumably function as rational targets for this disease. Gene fusions and translocations such as BCR-ABL in CML were thought to primarily be the basis of hematologic malignancies and sarcomas. The finding of recurrent gene fusions in prostate cancer potentially redefines the molecular basis of this disease as well as other common epithelial cancers. The team involved with these studies was awarded the 2007 AACR Team Science Award. The Chinnaiyan lab is focused on translating the prostate cancer gene fusion discovery into better diagnostics and therapies for prostate cancer.
To update protocols, publications, biomarkers, or science data, please contact the Data Management and Coordinating Center.
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- Site
- University of Michigan
- Degree(s)
- M.D., Ph.D.
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arul@umich.edu - Person ID
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1726 - Note
- To update contact information, please visit the Data Management and Coordinating Center .