Hollingsworth, Michael

Open Protocols

Protocol Name	Investigatory Role	Biomarkers	Data Collections
Biomarkers for the Early Detection of Pancreatic Cancer	Involved	0	0

Closed Protocols

Protocol Name	Investigatory Role	Data Collections
Antibodies Against Tumor Antigens or Mucin Epitopes in Ovarian Cancer	Involved	0
Early Diagnosis of Pancreatic Cancer-Network Collaborative Studies	Coordinating	0
Hollingsworth - Aggressive vs Indolent 2012	Leading	0
Pancreatic Reference Set Application: Michael Hollingsworth-University of Nebraska (2014)	Leading	1

Publications

Publication Name	PubMed ID	Journal
A micropapillary pattern is predictive of a poor prognosis in lung adenocarcinoma, and reduced surfactant apoprotein A expression in the micropapillary pattern is an excellent indicator of a poor prognosis.	17431413	Mod Pathol
Aberrant expression of MUC4 in ovarian carcinoma: diagnostic significance alone and in combination with MUC1 and MUC16 (CA125).	16880776	Mod Pathol
Aberrant expression of mucin core proteins and o-linked glycans associated with progression of pancreatic cancer.	23446997	Clin Cancer Res
Aberrant expression of transmembrane mucins, MUC1 and MUC4, in human prostate carcinomas.	16302265	Prostate
ADH-1 suppresses N-cadherin-dependent pancreatic cancer progression.	17721921	Int J Cancer
Biomarkers in Diagnosis of pancreatic carcinoma in fine-needle aspirates.	17019794	Am J Clin Pathol
Cancer metastasis facilitated by developmental pathways: Sonic hedgehog, Notch, and bone morphogenic proteins.	17914743	J Cell Biochem
CCL21 induces extensive intratumoral immune cell infiltration and specific anti-tumor cellular immunity.	17273764	Int J Oncol
Cell surface-associated mucins in signal transduction.	16904320	Trends Cell Biol
Cellular features of senescence during the evolution of human and murine ductal pancreatic cancer.	21860420	Oncogene
Characterization of human mucin MUC17. Complete coding sequence and organization.	16737958	J Biol Chem
Chemoenzymatically synthesized multimeric Tn/STn MUC1 glycopeptides elicit cancer-specific anti-MUC1 antibody responses and override tolerance.	16207894	Glycobiology
Chronic pancreatic inflammation induced by environmental tobacco smoke inhalation in rats.	16405548	Am J Gastroenterol
Class III beta-tubulin, a marker of resistance to paclitaxel, is overexpressed in pancreatic ductal adenocarcinoma and intraepithelial neoplasia.	17714470	Histopathology
Clinical potential of mucins in diagnosis, prognosis, and therapy of ovarian cancer.	19012856	Lancet Oncol
Complete suppression of tumor formation by high levels of basement membrane collagen.	18171981	Mol Cancer Res
Concise review: recent advances on the significance of stem cells in tissue regeneration and cancer therapies.	16794264	Stem Cells
Culture and immortalization of pancreatic ductal epithelial cells.	15542901	Methods Mol Med
Cyclin-dependent kinase 5 is amplified and overexpressed in pancreatic cancer and activated by mutant K-Ras.	21825040	Clin Cancer Res
Deregulation of MUC4 in gastric adenocarcinoma: potential pathobiological implication in poorly differentiated non-signet ring cell type gastric cancer.	18781152	Br J Cancer
Differential expression of metabolic genes in tumor and stromal components of primary and metastatic loci in pancreatic adenocarcinoma.	22412968	PLoS One
Dynamics of the immune reaction to pancreatic cancer from inception to invasion.	17909062	Cancer Res
Early diagnosis of pancreatic cancer: neutrophil gelatinase-associated lipocalin as a marker of pancreatic intraepithelial neoplasia.	18392050	Br J Cancer
Emerging roles of MUC4 in cancer: a novel target for diagnosis and therapy.	17234748	Cancer Res
Engineering antibodies for clinical applications.	17512622	Trends Biotechnol
ErbB2 growth factor receptor, a marker for neuroendocrine cells?	15775699	Pancreatology
Evaluation of MUC6 mucin tandem repeats.	15716126	Biochim Biophys Acta
Expression of core 3 synthase in human pancreatic cancer cells suppresses tumor growth and metastasis.	23754791	Int J Cancer
Functions of tumorigenic and migrating cancer progenitor cells in cancer progression and metastasis and their therapeutic implications.	17273942	Cancer Metastasis Rev
Generation and characterization of anti-MUC4 monoclonal antibodies reactive with normal and cancer cells in humans.	14729877	J Histochem Cytochem
Hedgehog inhibition prolongs survival in a genetically engineered mouse model of pancreatic cancer.	18515410	Gut
Human MUC4 mucin induces ultra-structural changes and tumorigenicity in pancreatic cancer cells.	17595659	Br J Cancer
Human RNA polymerase II-associated factor complex: dysregulation in cancer.	17599057	Oncogene
Inhibition of MUC4 expression suppresses pancreatic tumor cell growth and metastasis.	14744777	Cancer Res
Interactions between MUC1 and p120 catenin regulate dynamic features of cell adhesion, motility, and metastasis.	24371222	Cancer Res
Interplay of distinct growth factors during epithelial mesenchymal transition of cancer progenitor cells and molecular targeting as novel cancer therapies.	17355951	Ann Oncol
K-Ras promotes growth transformation and invasion of immortalized human pancreatic cells by Raf and phosphatidylinositol 3-kinase signaling.	17332339	Cancer Res
Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas.	17349581	Cancer Cell
Loss of fibulin-2 expression is associated with breast cancer progression.	17456760	Am J Pathol
MicroRNA-200c modulates the expression of MUC4 and MUC16 by directly targeting their coding sequences in human pancreatic cancer.	24204560	PLoS One
Modelling oncogenic Ras/Raf signalling in the mouse.	19201597	Curr Opin Genet Dev
MUC1 is a counter-receptor for myelin-associated glycoprotein (Siglec-4a) and their interaction contributes to adhesion in pancreatic cancer perineural invasion.	17974963	Cancer Res
MUC1 mucin stabilizes and activates hypoxia-inducible factor 1 alpha to regulate metabolism in pancreatic cancer.	22869720	Proc Natl Acad Sci U S A
MUC1 regulates expression of multiple microRNAs involved in pancreatic tumor progression, including the miR-200c/141 cluster.	24143167	PLoS One
MUC4 and MUC5AC are highly specific tumour-associated mucins in biliary tract cancer.	18475301	Br J Cancer
MUC4 expression correlates with poor prognosis in small-sized lung adenocarcinoma.	17126950	Lung Cancer
MUC4 expression is a novel prognostic factor in patients with invasive ductal carcinoma of the pancreas.	16049287	J Clin Pathol
MUC4 expression is regulated by cystic fibrosis transmembrane conductance regulator in pancreatic adenocarcinoma cells via transcriptional and post-translational mechanisms.	16799633	Oncogene
MUC4 is a novel prognostic factor of extrahepatic bile duct carcinoma.	16857800	Clin Cancer Res
MUC4 mucin interacts with and stabilizes the HER2 oncoprotein in human pancreatic cancer cells.	18381409	Cancer Res
MUC4 mucin potentiates pancreatic tumor cell proliferation, survival, and invasive properties and interferes with its interaction to extracellular matrix proteins.	17406026	Mol Cancer Res
MUC4, a multifunctional transmembrane glycoprotein, induces oncogenic transformation of NIH3T3 mouse fibroblast cells.	19010895	Cancer Res
MUC4-expressing pancreatic adenocarcinomas show elevated levels of both T1 and T2 cytokines: potential pathobiologic implications.	17032197	Am J Gastroenterol
MUC4-mediated regulation of acute phase protein lipocalin 2 through HER2/AKT/NF-κB signaling in pancreatic cancer.	24240113	Clin Cancer Res
Mucin expression in pleomorphic adenoma of salivary gland: a potential role for MUC1 as a marker to predict recurrence.	15280401	J Clin Pathol
Mucins in cancer: protection and control of the cell surface.	14681689	Nat Rev Cancer
Notch 2-positive progenitors with the intrinsic ability to give rise to pancreatic ductal cells.	15924149	Lab Invest
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis.	21734707	Nature
Optimization of radioimmunotherapy of solid tumors: biological impediments and their modulation.	17309914	Clin Cancer Res
Overexpression of ecdysoneless in pancreatic cancer and its role in oncogenesis by regulating glycolysis.	22977192	Clin Cancer Res
Overexpression of GalNAc-transferase GalNAc-T3 promotes pancreatic cancer cell growth.	21625220	Oncogene
Palladin is overexpressed in the non-neoplastic stroma of infiltrating ductal adenocarcinomas of the pancreas, but is only rarely overexpressed in neoplastic cells.	17404500	Cancer Biol Ther
Pancreatic enzyme extract improves survival in murine pancreatic cancer.	15097858	Pancreas
Pathobiological implications of MUC16 expression in pancreatic cancer.	22066010	PLoS One
Pathology of genetically engineered mouse models of pancreatic exocrine cancer: consensus report and recommendations.	16397221	Cancer Res
Phosphorylation of MUC1 by Met modulates interaction with p53 and MMP1 expression.	18625714	J Biol Chem
Platelet-derived growth factor receptor beta-mediated phosphorylation of MUC1 enhances invasiveness in pancreatic adenocarcinoma cells.	17545600	Cancer Res
Ras-driven transformation of human nestin-positive pancreatic epithelial cells.	18374182	Methods Enzymol
Recent advances in cancer stem/progenitor cell research: therapeutic implications for overcoming resistance to the most aggressive cancers.	17979879	J Cell Mol Med
Recent advances on multiple tumorigenic cascades involved in prostatic cancer progression and targeting therapies.	16195239	Carcinogenesis
Recent advances on the molecular mechanisms involved in pancreatic cancer progression and therapies.	16258363	Pancreas
Recent advances on the molecular mechanisms involved in the drug resistance of cancer cells and novel targeting therapies.	17786164	Clin Pharmacol Ther
Recent progress on normal and malignant pancreatic stem/progenitor cell research: therapeutic implications for the treatment of type 1 or 2 diabetes mellitus and aggressive pancreatic cancer.	18791122	Gut
Recent progress on tissue-resident adult stem cell biology and their therapeutic implications.	18288619	Stem Cell Rev
Regulation of mucin expression: mechanistic aspects and implications for cancer and inflammatory diseases.	16487661	Biochim Biophys Acta
Relevance of MUC1 mucin variable number of tandem repeats polymorphism in H pylori adhesion to gastric epithelial cells.	18322957	World J Gastroenterol
Rosiglitazone and Gemcitabine in combination reduces immune suppression and modulates T cell populations in pancreatic cancer.	22864396	Cancer Immunol Immunother
Sonic hedgehog paracrine signaling regulates metastasis and lymphangiogenesis in pancreatic cancer.	19633682	Oncogene
Sonic hedgehog promotes desmoplasia in pancreatic cancer.	18829478	Clin Cancer Res
Stem cells: a revolution in therapeutics-recent advances in stem cell biology and their therapeutic applications in regenerative medicine and cancer therapies.	17671448	Clin Pharmacol Ther
Structure, evolution, and biology of the MUC4 mucin.	18024835	FASEB J
Targeting of cancer stem/progenitor cells plus stem cell-based therapies: the ultimate hope for treating and curing aggressive and recurrent cancers.	18427384	Panminerva Med
The human homologue of the RNA polymerase II-associated factor 1 (hPaf1), localized on the 19q13 amplicon, is associated with tumorigenesis.	16491129	Oncogene
The lectin domains of polypeptide GalNAc-transferases exhibit carbohydrate-binding specificity for GalNAc: lectin binding to GalNAc-glycopeptide substrates is required for high density GalNAc-O-glycosylation.	17215257	Glycobiology
The MUC gene family: their role in the diagnosis and prognosis of gastric cancer.	18830939	Histol Histopathol
The reactive tumor microenvironment: MUC1 signaling directly reprograms transcription of CTGF.	20697347	Oncogene
Transcriptional regulation of human mucin MUC4 by bile acids in oesophageal cancer cells is promoter-dependent and involves activation of the phosphatidylinositol 3-kinase signalling pathway.	14583090	Biochem J
Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice.	15894267	Cancer Cell
Tumor suppression by collagen XV is independent of the restin domain.	22531369	Matrix Biol

Interests

Pancreatic Cancer: Identify, develop and validate markers for early diagnosis of pancreatic cancer

To update protocols, publications, biomarkers, or science data, please contact the Data Management and Coordinating Center.

Site: University of Nebraska Medical Center
Degree(s): Ph.D.
Email: mahollin@unmc.edu
Fax: 402-559-2813
Person ID: 1728
EDRN Title: EDRN Associate Member
Note: To update contact information, please visit the Data Management and Coordinating Center .