Open Protocols

Protocol Name	Investigatory Role	Biomarkers	Data Collections
Light Scattering Spectroscopy for the Detection of Colorectal Neoplasia	Involved	0	0
Spectral Markers for Early Detection of Colon Neoplasia	Coordinating	0	0

Closed Protocols

Protocol Name	Investigatory Role	Biomarkers	Data Collections
Prevalidation for Rectal PWS for Colon Cancer Screening	Leading	1	0

Publications

Publication Name	PubMed ID	Journal
Assessment of blood supply in superficial tissue by polarization-gated elastic light-scattering spectroscopy.	16422163	Appl Opt
Association of stem-like cells in gender-specific chemoprevention against intestinal neoplasia in MIN mouse.	21769438	Oncol Rep
Associations between the age at diagnosis and location of colorectal cancer and the use of alcohol and tobacco: implications for screening.	16567601	Arch Intern Med
Biomarkers for the early detection of cancer: an inflammatory concept.	17893302	Arch Intern Med
Chemoprevention of colon carcinogenesis by polyethylene glycol: suppression of epithelial proliferation via modulation of SNAIL/beta-catenin signaling.	16928827	Mol Cancer Ther
Colon cancer screening: the good, the bad, and the ugly.	17101934	Arch Intern Med
Colonoscopy and optical biopsy: bridging technological advances to clinical practice.	21521641	Gastroenterology
Depth-resolved low-coherence enhanced backscattering.	15832924	Opt Lett
Down-regulation of SNAIL suppresses MIN mouse tumorigenesis: modulation of apoptosis, proliferation, and fractal dimension.	15367710	Mol Cancer Ther
Down-regulation of the tumor suppressor gene C-terminal Src kinase: an early event during premalignant colonic epithelial hyperproliferation.	15961079	FEBS Lett
Four-dimensional elastic light-scattering fingerprints as preneoplastic markers in the rat model of colon carcinogenesis.	15057746	Gastroenterology
Increased microvascular blood content is an early event in colon carcinogenesis.	15831911	Gut
Inducible nitric oxide synthase (iNOS) mediates the early increase of blood supply (EIBS) in colon carcinogenesis.	17658518	FEBS Lett
Involvement of p21cip1/waf1 in the anti-proliferative effects of polyethylene glycol in colon carcinogenesis.	21170505	Int J Oncol
Light-scattering technologies for field carcinogenesis detection: a modality for endoscopic prescreening.	21078318	Gastroenterology
Low-coherence enhanced backscattering: review of principles and applications for colon cancer screening.	16965153	J Biomed Opt
Low-coherent backscattering spectroscopy for tissue characterization.	15717826	Appl Opt
Moving toward personalization of colorectal cancer screening: Comment on "Influence of race and sex on prevalence and recurrence of colon polyps".	20625019	Arch Intern Med
Nanocytology for field carcinogenesis detection: novel paradigm for lung cancer risk stratification.	21174531	Future Oncol
Neo-angiogenesis and the premalignant micro-circulatory augmentation of early colon carcinogenesis.	21493000	Cancer Lett
Optical detection of buccal epithelial nanoarchitectural alterations in patients harboring lung cancer: implications for screening.	20924114	Cancer Res
Optical markers in duodenal mucosa predict the presence of pancreatic cancer.	17671121	Clin Cancer Res
Optical measurement of rectal microvasculature as an adjunct to flexible sigmoidosocopy: gender-specific implications.	20570881	Cancer Prev Res (Phila)
Polyethylene glycol inhibits intestinal neoplasia and induces epithelial apoptosis in Apc(min) mice.	15374630	Cancer Lett
Practicing medicine at the front lines of the genomic revolution.	16157823	Arch Intern Med
Risk of colon cancer in hereditary non-polyposis colorectal cancer patients as predicted by fuzzy modeling: Influence of smoking.	16874859	World J Gastroenterol
Risk stratification of colon carcinogenesis through enhanced backscattering spectroscopy analysis of the uninvolved colonic mucosa.	16467111	Clin Cancer Res
Spectral markers in preneoplastic intestinal mucosa: an accurate predictor of tumor risk in the MIN mouse.	16030095	Cancer Epidemiol Biomarkers Prev
The association between aspirin use and the incidence of colorectal cancer in women.	16847042	Am J Epidemiol
The nonsteroidal anti-inflammatory drug, nabumetone, differentially inhibits beta-catenin signaling in the MIN mouse and azoxymethane-treated rat models of colon carcinogenesis.	15617833	Cancer Lett
The transcriptional repressor SNAIL is overexpressed in human colon cancer.	15712635	Dig Dis Sci
Tobacco use and increased colorectal cancer risk in patients with hereditary nonpolyposis colorectal cancer (Lynch syndrome).	15596632	Arch Intern Med

Interests

Biomarkers of Colon cancer

We are currently involved in the development of spectral signatures as a marker for the "field effect" of colon carcinogenesis. We believe that this will enable risk stratification

Sprectral Markers for Colon Carcinogenesis Detection

Our group is interested in using novel light scattering approaches to detect field changes of colon carcinogenesis and hence allow risk stratification of colon carcinogenesis

To update protocols, publications, biomarkers, or science data, please contact the Data Management and Coordinating Center.

Site

Boston University

Degree(s)

M.D.

Email

hkroy@bu.edu

Fax

847-733-5041

Person ID

1731

EDRN Title

EDRN Associate Member

Note

To update contact information, please visit the Data Management and Coordinating Center .