Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted.

The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit https://cc.nih.gov.

Updates regarding government operating status and resumption of normal operations can be found at OPM.gov.

Log in

Li, Christopher

Open Protocols

Protocol Name	Investigatory Role	Biomarkers	Data Collections
Biomarkers to Distinguish Aggressive Cancers from Non-aggressive or Non-progressing Cancer	Coordinating	0	0
BRS Reference Set-Li C-2025	Leading	0	0
EDRN Breast and Ovary Cancer CVC, Study 1: Preliminary validation of breast cancer early detection biomarker candidates from our WHI discovery project	Coordinating	0	0
EDRN Breast and Ovary Cancer CVC, Study 2: Phase 3 retrospective validation of ovarian cancer early detection markers in serial preclinical samples from the PLCO trial	Leading	0	0
EDRN Breast and Ovary Cancer CVC, Study 3: Phase 3 Validation of screening decision rules in preclinical UKCTOCS serial samples	Leading	0	0
EDRN Breast and Ovary Cancer CVC, Study 4: Phase 3 Validation of Ovarian Cancer Serum Markers in Preclinical WHI Samples	Leading	0	0
Identification of biomarkers for ER+ breast cancer	Leading	0	0
Phase 3 Validation of Biomarkers for the Early Detection of ER+ Breast Cancer	Leading	0	0
Study 5: Phase 2 and 3 Validations of Putative Breast Cancer Early Detection Candidates	Leading	0	0
Validation of Early Detection Ovarian Cancer Biomarkers (Team Project)	Involved	149	0

Closed Protocols

Protocol Name	Investigatory Role	Biomarkers	Data Collections
Benign Breast Disease Team Project	Involved	25	1
Breast Reference Set Application: Chris Li-FHCRC (2013)	Leading	10	0
Breast Reference Set Application: Chris Li-FHCRC (2015)	Leading	10	0
DCIS Team Project	Leading	6	1
Triple Negative Breast Cancer Team Project	Involved	147	0

Publications

Publication Name	PubMed ID	Journal
Candidate early detection protein biomarkers for ER+/PR+ invasive ductal breast carcinoma identified using pre-clinical plasma from the WHI observational study.	26319120	Breast Cancer Res Treat
Dermcidin expression is associated with disease progression and survival among breast cancer patients.	24562771	Breast Cancer Res Treat
Designing early detection programs for ovarian cancer.	22180403	Ann Oncol
Discovery and preliminary confirmation of novel early detection biomarkers for triple-negative breast cancer using preclinical plasma samples from the Women's Health Initiative observational study.	22903690	Breast Cancer Res Treat
Discovery of novel plasma proteins as biomarkers for the development of incisional hernias after midline incision in patients with colorectal cancer: The ColoCare study.	27745870	Surgery
Early-Phase Studies of Biomarkers: What Target Sensitivity and Specificity Values Might Confer Clinical Utility?	27001493	Clin Chem
Evaluation of ovarian cancer remission markers HE4, MMP7 and Mesothelin by comparison to the established marker CA125.	22155417	Gynecol Oncol
Identifying post-menopausal women at elevated risk for epithelial ovarian cancer.	26343159	Gynecol Oncol
Immunity to placental malaria. III. Impairment of interleukin(IL)-12, not IL-18, and interferon-inducible protein-10 responses in the placental intervillous blood of human immunodeficiency virus/malaria-coinfected women.	11756993	J Infect Dis
Impact of screening test performance and cost on mortality reduction and cost-effectiveness of multimodal ovarian cancer screening.	22750949	Cancer Prev Res (Phila)
Interpretation of single and serial measures of HE4 and CA125 in asymptomatic women at high risk for ovarian cancer.	22962406	Cancer Epidemiol Biomarkers Prev
JAK2 expression is associated with tumor-infiltrating lymphocytes and improved breast cancer outcomes: implications for evaluating JAK2 inhibitors.	24764577	Cancer Immunol Res
Longitudinal screening algorithm that incorporates change over time in CA125 levels identifies ovarian cancer earlier than a single-threshold rule.	23248253	J Clin Oncol
Potential role of HE4 in multimodal screening for epithelial ovarian cancer.	21917606	J Natl Cancer Inst
Protein and glycomic plasma markers for early detection of adenoma and colon cancer.	27821646	Gut
Proteomic Analysis, Immune Dysregulation, and Pathway Interconnections with Obesity.	27769113	J Proteome Res
Recommendation to use exact P-values in biomarker discovery research in place of approximate P-values.	30099328	Cancer Epidemiol

Interests

Discovery and Validation of Breast Cancer Early Detection Biomarkers: We are actively engaged in breast cancer early detection biomarker discovery and validation using multiple proteomic platforms. Our focus is on use of high quality, well annotated preclinical blood specimens.

To update protocols, publications, biomarkers, or science data, please contact the Data Management and Coordinating Center.

Site: Fred Hutchinson Cancer Center
Degree(s): M.D., Ph.D.
Email: cili@fredhutch.org
Person ID: 1736
EDRN Title: EDRN Principal Investigator
Note: To update contact information, please visit the Data Management and Coordinating Center .