Open Protocols

Protocol Name	Investigatory Role	Biomarkers	Data Collections
Clinical Validation Center for Hepatocellular Carcinoma	Coordinating	0	0
HEDS Ref Set App: Hoshida (2024) Validation of etiology-specific "plug-in" PLSec assays	Involved	0	0
HEDS Ref Set App: Singal (2024) Longitudinal changes in PLSec biomarker and HCC risk in the HEDS cohort	Involved	0	0
Hepatocellular carcinoma Early Detection Strategy study	Involved	1	0
Liver Rapid Reference Set Mehta-Singal (2022)	Involved	0	0
National Liver Cancer Screening Trial (TRACER)	Leading	0	0

Closed Protocols

Protocol Name	Investigatory Role	Biomarkers	Data Collections
HEDS Reference Set Application: Amit Singal, UTSW (2021) Prognostic Liver Secretome signature Validation	Leading	0	0

Publications

Publication Name	PubMed ID	Journal
A Biomarker Panel Based upon AFP, Fucosylated Kininogen and PEG-Precipitated IgG Is Highly Accurate for the Early Detection Hepatocellular Carcinoma in Patients with Cirrhosis in Phase II and Phase III Biomarker Evaluation.	36497452	Cancers (Basel)
Blood-Based Biomarkers for HCC Surveillance: Ready for the Center Stage?	37795908	Am J Gastroenterol
GP73, a resident Golgi glycoprotein, is a novel serum marker for hepatocellular carcinoma.	16137783	J Hepatol
Increased levels of galactose-deficient anti-Gal immunoglobulin G in the sera of hepatitis C virus-infected individuals with fibrosis and cirrhosis.	18045939	J Virol
Longitudinal changes in fibrosis markers are associated with risk of cirrhosis and hepatocellular carcinoma in non-alcoholic fatty liver disease.	36402450	J Hepatol
SELDI-TOF MS profiling of serum for detection of the progression of chronic hepatitis C to hepatocellular carcinoma.	15726646	Hepatology
Survival following liver transplantation for hepatocellular carcinoma after implementation of MMaT-3 policy.	37129867	Liver Transpl

Interests

Hepatocellular carcinoma

My research focuses on risk stratification and early detection of liver cancer in patients with cirrhosis, including evaluation of emerging blood- and imaging-based screening strategies.

To update protocols, publications, biomarkers, or science data, please contact the Data Management and Coordinating Center.

Site

UT Southwestern Medical Center

Degree(s)

M.D.

Email

amit.singal@utsouthwestern.edu

Person ID

4686

EDRN Title

EDRN Principal Investigator

Note

To update contact information, please visit the Data Management and Coordinating Center .