Open Protocols

Protocol Name	Investigatory Role	Biomarkers	Data Collections
A Methylation Panel for Bladder Cancer	Coordinating	0	0
Aurora Kinase A as a Biomarker for the Detection of Bladder Cancer - Supplemental Pre-Validation Protocol	Involved	0	0
Early Molecular Detection of Invasive Bladder Cancer by Urine Examination	Involved	0	0
Research Depository of Normal and Neoplastic Human Tissues	Coordinating	0	0

Closed Protocols

Protocol Name	Investigatory Role	Biomarkers	Data Collections
Early Detection of Urinary Bladder Cancer	Involved	0	0
Identification of biomarkers for lung cancer in never smokers	Leading	4	1
Polyp Prediction Study	Involved	0	0
Presence of simian virus 40 DNA sequences in human	Coordinating	0	0
Protocol for Comparing Promoter Hypermethylation Methods in NSCLC	Involved	0	0

Publications

Publication Name	PubMed ID	Journal
Aberrant methylation and simian virus 40 tag sequences in malignant mesothelioma.	11479207	Cancer Res
Aberrant methylation during cervical carcinogenesis.	11297252	Clin Cancer Res
Aberrant methylation of HIN-1 (high in normal-1) is a frequent event in many human malignancies.	15472908	Int J Cancer
Aberrant methylation of Reprimo in human malignancies.	15700311	Int J Cancer
Aberrant methylation of SPARC in human lung cancers.	15756262	Br J Cancer
Aberrant methylation of the CDH13 (H-cadherin) promoter region in colorectal cancers and adenomas.	12067979	Cancer Res
Aberrant methylation of the HPP1 gene in ulcerative colitis-associated colorectal carcinoma.	12460892	Cancer Res
Aberrant methylation of TMS1 in small cell, non small cell lung cancer and breast cancer.	12800194	Int J Cancer
Aberrant methylation of trail decoy receptor genes is frequent in multiple tumor types.	14999791	Int J Cancer
Aberrant methylation profile of human malignant mesotheliomas and its relationship to SV40 infection.	15592515	Oncogene
Aberrant promoter hypermethylation of multiple genes in gallbladder carcinoma and chronic cholecystitis.	15447999	Clin Cancer Res
Aberrant promoter methylation and silencing of laminin-5-encoding genes in breast carcinoma.	14695139	Clin Cancer Res
Aberrant promoter methylation and silencing of the RASSF1A gene in pediatric tumors and cell lines.	12082624	Oncogene
Aberrant promoter methylation of laminin-5-encoding genes in prostate cancers and its relationship to clinicopathological features.	14695140	Clin Cancer Res
Aberrant promoter methylation of multiple genes during multistep pathogenesis of colorectal cancers.	16108009	Int J Cancer
Aberrant promoter methylation profile of bladder cancer and its relationship to clinicopathological features.	11751381	Cancer Res
Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines.	19238210	PLoS One
Application of a methylation gene panel by quantitative PCR for lung cancers.	16644104	Cancer Lett
Application of Multidimensional Selective Item Response Regression Model for Studying Multiple Gene Methylation in SV40 Oncogenic Pathways.	19830254	J Am Stat Assoc
Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers.	15741570	J Natl Cancer Inst
Cytoglobin, the newest member of the globin family, functions as a tumor suppressor gene.	18794132	Cancer Res
Deletions of chromosome 4 occur early during the pathogenesis of colorectal carcinoma.	11230704	Hum Pathol
Deregulated EGFR signaling during lung cancer progression: mutations, amplicons, and autocrine loops.	19138950	Cancer Prev Res (Phila)
Differential expression of FEZ1/LZTS1 gene in lung cancers and their cell cultures.	12114433	Clin Cancer Res
Differential methylation of a short CpG-rich sequence within exon 1 of TCF21 gene: a promising cancer biomarker assay.	18398044	Cancer Epidemiol Biomarkers Prev
Differential methylation of genes that regulate cytokine signaling in lymphoid and hematopoietic tumors.	15580314	Oncogene
DNA methylation in health, disease, and cancer.	17311535	Curr Mol Med
DNA methylation profiles of lung tumors.	12467239	Mol Cancer Ther
DNA methylation profiles of lymphoid and hematopoietic malignancies.	15131027	Clin Cancer Res
DNA methylation-associated inactivation of TGFbeta-related genes DRM/Gremlin, RUNX3, and HPP1 in human cancers.	16234815	Br J Cancer
Epigenetic down-regulation of death-associated protein kinase in lung cancers.	12912953	Clin Cancer Res
Establishment and validation of real-time polymerase chain reaction method for CDH1 promoter methylation.	12163387	Am J Pathol
Evaluation of candidate methylation markers to detect cervical neoplasia.	17894941	Gynecol Oncol
Evidence for alternative candidate genes near RB1 involved in clonal expansion of in situ urothelial neoplasia.	16402033	Lab Invest
Filling the void: urinary markers for bladder cancer risk and diagnosis.	11259458	J Natl Cancer Inst
Genomic alterations in cultured human embryonic stem cells.	16142235	Nat Genet
High-resolution chromosome 3p allelotyping of breast carcinomas and precursor lesions demonstrates frequent loss of heterozygosity and a discontinuous pattern of allele loss.	11438460	Am J Pathol
Inactivation of cyclin D2 gene in prostate cancers by aberrant promoter methylation.	14581343	Clin Cancer Res
Loss of expression and aberrant methylation of the CDH13 (H-cadherin) gene in breast and lung carcinomas.	11389090	Cancer Res
Methods for detecting DNA methylation in tumors: from bench to bedside.	17166656	Cancer Lett
Methylation of apoptosis related genes in the pathogenesis and prognosis of prostate cancer.	16458425	Cancer Lett
Molecular detection of noninvasive and invasive bladder tumor tissues and exfoliated cells by aberrant promoter methylation of laminin-5 encoding genes.	14973053	Cancer Res
Multifocal lung cancers--clonality vs field cancerization and does it matter?	19351914	J Natl Cancer Inst
Mutations and addiction to EGFR: the Achilles 'heal' of lung cancers?	15464447	Trends Mol Med
Novel real-time PCR assay using a universal molecular marker for diagnosis of hematologic cancers.	15825171	Int J Cancer
Polymorphisms, mutations, and amplification of the EGFR gene in non-small cell lung cancers.	17455987	PLoS Med
Presence of simian virus 40 DNA sequences in human lymphoid and hematopoietic malignancies and their relationship to aberrant promoter methylation of multiple genes.	15172980	Cancer Res
Presence of simian virus 40 DNA sequences in human lymphomas.	11897287	Lancet
Progressive aberrant methylation of the RASSF1A gene in simian virus 40 infected human mesothelial cells.	12082623	Oncogene
Smoke exposure, histologic type and geography-related differences in the methylation profiles of non-small cell lung cancer.	12455028	Int J Cancer
Somatic mutations of the HER2 kinase domain in lung adenocarcinomas.	15753357	Cancer Res
Sun exposure related methylation in malignant and non-malignant skin lesions.	16494996	Cancer Lett
SV40 and human tumours: myth, association or causality?	12459734	Nat Rev Cancer
Understanding the development of human bladder cancer by using a whole-organ genomic mapping strategy.	18458673	Lab Invest

Interests

Molecular pathogenesis of early cancer

The major focus of my EDRN research interests are the early diagnosis and risk assessment of human cancers. While the major emphasis is on lung and breast cancers, several other types including bladder, prostate and cervix are studied. We have built up large collections of tissues from these tumor types and auxillary materials including non-malignant tissues adjacent to invasive cancers, and tissues (bronchial brushes, sputa, ducatl lavages, FNAs etc) from subjects at increased risk. These are analyzed for molecular markers for susceptibility and early invasion. Recent emphasis has been on markers that indicate disruption of the basement membrane and which should distinguish in situ from invasive cancers.

To update protocols, publications, biomarkers, or science data, please contact the Data Management and Coordinating Center.

Site

UT Southwestern Medical Center

Degree(s)

M.D.

Email

adi.gazdar@utsouthwestern.edu

Fax

(214) 648-4940

Person ID

1004

EDRN Title

EDRN Associate Member

Note

To update contact information, please visit the Data Management and Coordinating Center .