Maitra, Anirban

Open Protocols

Protocol Name	Investigatory Role	Biomarkers
A Prospective Study to Establish a New Onset Hyperglycemia and Diabetes (NOD) Cohort	Involved	0
Development of Tissue Microarray Resource for Pancreatic Cancer	Involved	0
NOD Reference Set Application - Fahrmann (2023)	Involved	0
Pre-diagnostic Pancreatic Cancer Set Aside Project	Involved	25
Technical and clinical validation of imaging biomarkers for early detection of pancreatic cancer	Leading	0

Closed Protocols

Protocol Name	Investigatory Role	Biomarkers	Data Collections
A Biomarker Bakeoff in Early Stage Pancreatic Cancer	Involved	11	0
Pancreatic Cancer Bake Off 2	Involved	4	0
Pancreatic Prediagnostic Imaging Repository	Leading	0	0
The Development of Targeted Therapeutic Approaches for Pancreatic Cancer	Coordinating	0	1

Publications

Publication Name	PubMed ID	Journal
4-1BB Agonist Focuses CD8<sup>+</sup> Tumor-Infiltrating T-Cell Growth into a Distinct Repertoire Capable of Tumor Recognition in Pancreatic Cancer.	28947567	Clin Cancer Res
A blood-based metabolomic signature predictive of risk for pancreatic cancer.	37729870
Altered hydroxymethylation is seen at regulatory regions in pancreatic cancer and regulates oncogenic pathways.	28986391	Genome Res
An Approach To Fabricate PDMS Encapsulated All-Solid-State Advanced Asymmetric Supercapacitor Device with Vertically Aligned Hierarchical Zn-Fe-Co Ternary Oxide Nanowire and Nitrogen Doped Graphene Nanosheet for High Power Device Applications.	28094497	ACS Appl Mater Interfaces
Association of Clinical Factors With a Major Pathologic Response Following Preoperative Therapy for Pancreatic Ductal Adenocarcinoma.	28700784	JAMA Surg
Cellular heterogeneity during mouse pancreatic ductal adenocarcinoma progression at single-cell resolution.	31335328	JCI Insight
Circulating Nucleic Acids Are Associated With Outcomes of Patients With Pancreatic Cancer.	30240661	Gastroenterology
Combination of PD-1 Inhibitor and OX40 Agonist Induces Tumor Rejection and Immune Memory in Mouse Models of Pancreatic Cancer.	32179091	Gastroenterology
Combined circulating tumor DNA and protein biomarker-based liquid biopsy for the earlier detection of pancreatic cancers.	28874546	Proc Natl Acad Sci U S A
Contributions of the Microbiome-Derived Metabolome for Risk Assessment and Prognostication of Pancreatic Cancer.	38175578
Current and emerging radiotherapy strategies for pancreatic adenocarcinoma: stereotactic, intensity modulated and particle radiotherapy.	30198024	Ann Pancreat Cancer
Current Status and Future Directions for Screening Patients at High Risk for Pancreatic Cancer.	28656024	Gastroenterol Hepatol (N Y)
Diagnostic value of digital droplet polymerase chain reaction and digital multiplexed detection of single-nucleotide variants in pancreatic cytology specimens collected by EUS-guided FNA.	33058885	Gastrointest Endosc
Dose escalation of radiotherapy in unresectable extrahepatic cholangiocarcinoma.	30152073	Cancer Med
Early Detection of Pancreatic Cancer-a Defined Future Using Lessons From Other Cancers: A White Paper.	27518362	Pancreas
Early Detection of Pancreatic Cancer: Opportunities and Challenges.	30721664	Gastroenterology
Early Detection of Sporadic Pancreatic Ductal Adenocarcinoma: Problems, Promise, and Prospects.	32176886	Ann Intern Med
Enhancement pattern mapping technique for improving contrast-to-noise ratios and detectability of hepatobiliary tumors on multiphase computed tomography.	31449684	Med Phys
Epithelial memory of inflammation limits tissue damage while promoting pancreatic tumorigenesis.	34529467	Science
Exosomes harbor B cell targets in pancreatic adenocarcinoma and exert decoy function against complement-mediated cytotoxicity.	30651550	Nat Commun
Exploiting the neoantigen landscape for immunotherapy of pancreatic ductal adenocarcinoma.	27762323	Sci Rep
Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer.	28099419	Nature
GNAS<sup>R201C</sup> Induces Pancreatic Cystic Neoplasms in Mice That Express Activated KRAS by Inhibiting YAP1 Signaling.	30142336	Gastroenterology
Imaging-based biomarkers: Changes in the tumor interface of pancreatic ductal adenocarcinoma on computed tomography scans indicate response to cytotoxic therapy.	29370450	Cancer
Influence of Preoperative Therapy on Short- and Long-Term Outcomes of Patients with Adenocarcinoma of the Ampulla of Vater.	28124275	Ann Surg Oncol
Intercepting Pancreatic Cancer: Our Dream Team's Resolve to Stop Pancreatic Cancer.	30325853	Pancreas
Isolation and mutational assessment of pancreatic cancer extracellular vesicles using a microfluidic platform.	32162067	Biomed Microdevices
Krüppel-Like Factor 4 Promotes Pancreatic Acinar-to-Ductal Metaplasia and Tumor Initiation.	28085752	Pancreas
Lead-Time Trajectory of CA19-9 as an Anchor Marker for Pancreatic Cancer Early Detection.	33333055	Gastroenterology
Liquid biopsies in pancreatic cancer.	31533487	Expert Rev Anticancer Ther
Macropinocytosis of Nab-paclitaxel Drives Macrophage Activation in Pancreatic Cancer.	28108630	Cancer Immunol Res
Mathematical prediction of clinical outcomes in advanced cancer patients treated with checkpoint inhibitor immunotherapy.	32426472	Sci Adv
Membrane-bound MMP-14 protease-activatable adeno-associated viral vectors for gene delivery to pancreatic tumors.	33958732	Gene Ther
Overexpression of CD73 in pancreatic ductal adenocarcinoma is associated with immunosuppressive tumor microenvironment and poor survival.	33832821	Pancreatology
Pancreatic Cancer Genomics 2.0: Profiling Metastases.	28292434	Cancer Cell
Pancreatic cancer hidden in plain sight.	32322029	Nature
Pancreatic cancer in 2017: Rebooting pancreatic cancer knowledge and treatment options.	29317774	Nat Rev Gastroenterol Hepatol
Plasma miRNA Biomarkers in Limited Volume Samples for Detection of Early-stage Pancreatic Cancer.	33893071	Cancer Prev Res (Phila)
Potential of artificial intelligence in the risk stratification for and early detection of pancreatic cancer.	37124705
Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine.	28912244	Science
Potentially Curable Pancreatic Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update.	28398845	J Clin Oncol
Preclinical Rationale for the Phase III Trials in Metastatic Pancreatic Cancer: Is Wishful Thinking Clouding Successful Drug Development for Pancreatic Cancer?	28085753	Pancreas
Preoperative Therapy and Pancreatoduodenectomy for Pancreatic Ductal Adenocarcinoma: a 25-Year Single-Institution Experience.	27778257	J Gastrointest Surg
Prognostic Significance of New AJCC Tumor Stage in Patients With Pancreatic Ductal Adenocarcinoma Treated With Neoadjuvant Therapy.	28614206	Am J Surg Pathol
Prognostic Significance of Tumor-Infiltrating Lymphocytes in Patients With Pancreatic Ductal Adenocarcinoma Treated With Neoadjuvant Chemotherapy.	28902789	Pancreas
Protein biomarkers and alternatively methylated cell-free DNA detect early stage pancreatic cancer.	38123998
Quantitative imaging to evaluate malignant potential of IPMNs.	27588410	Oncotarget
Radiation-Induced Liver Disease and Modern Radiotherapy.	30309642	Semin Radiat Oncol
Recent advances in genomic profiling of adenosquamous carcinoma of the pancreas.	28816351	J Pathol
Reduced expression of argininosuccinate synthetase 1 has a negative prognostic impact in patients with pancreatic ductal adenocarcinoma.	28187218	PLoS One
Roles and Regulations of TET Enzymes in Solid Tumors.	33468438	Trends Cancer
Sequential Validation of Blood-Based Protein Biomarker Candidates for Early-Stage Pancreatic Cancer.	28376157	J Natl Cancer Inst
Simultaneous inhibition of hedgehog signaling and tumor proliferation remodels stroma and enhances pancreatic cancer therapy.	29331808	Biomaterials
Single-cell RNA sequencing in pancreatic cancer.	34040169	Nat Rev Gastroenterol Hepatol
Single-Cell Transcriptomics of Pancreatic Cancer Precursors Demonstrates Epithelial and Microenvironmental Heterogeneity as an Early Event in Neoplastic Progression.	30385653	Clin Cancer Res
Slicing and Dicing Pancreatic Cancer Into Actionable Nuggets.	28476743	J Natl Compr Canc Netw
Small-Molecule Inhibition of Axl Targets Tumor Immune Suppression and Enhances Chemotherapy in Pancreatic Cancer.	29180468	Cancer Res
Superior therapeutic efficacy of nab-paclitaxel over cremophor-based paclitaxel in locally advanced and metastatic models of human pancreatic cancer.	27441498	Br J Cancer
Surfaceome profiling enables isolation of cancer-specific exosomal cargo in liquid biopsies from pancreatic cancer patients.	29045505	Ann Oncol
Surgical overtreatment of pancreatic intraductal papillary mucinous neoplasms: Do the 2017 International Consensus Guidelines improve clinical decision making?	30170819	Surgery
Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer.	28178232	Nature
The extracellular matrix and focal adhesion kinase signaling regulate cancer stem cell function in pancreatic ductal adenocarcinoma.	28692661	PLoS One
The role of stromal cancer-associated fibroblasts in pancreatic cancer.	28351381	J Hematol Oncol
The sTRA Plasma Biomarker: Blinded Validation of Improved Accuracy Over CA19-9 in Pancreatic Cancer Diagnosis.	30617132	Clin Cancer Res
Treatment of Pancreatic Cancer Patient-Derived Xenograft Panel with Metabolic Inhibitors Reveals Efficacy of Phenformin.	28611197	Clin Cancer Res
Two cases of non-cystic fibrosis (CF) bronchiectasis with allergic bronchopulmonary aspergillosis.	28053855	Respir Med Case Rep
Upfront molecular profiling of pancreatic cancer patients - An idea whose time has come.	32192904	Pancreatology
Validation of a Proposed Tumor Regression Grading Scheme for Pancreatic Ductal Adenocarcinoma After Neoadjuvant Therapy as a Prognostic Indicator for Survival.	27631521	Am J Surg Pathol

Interests

Pancreatic Cancer: Early detection, liquid biopsies, exosomes, cystic lesions.

To update protocols, publications, biomarkers, or science data, please contact the Data Management and Coordinating Center.

Site: The University of Texas M D Anderson Cancer Center
Degree(s): M.B.B.S.
Email: anirban.maitra@nyulangone.org
Person ID: 3681
EDRN Title: EDRN Principal Investigator
Note: To update contact information, please visit the Data Management and Coordinating Center .