Open Protocols

This person has no open protocols at the present moment.

Closed Protocols

Protocol Name	Investigatory Role	Biomarkers	Data Collections
Barretts Esophagus Methylation Profiles	Leading	11	1
Polyp Prediction Study	Coordinating	0	0

Publications

Publication Name	PubMed ID	Journal
A genome-wide search identifies epigenetic silencing of somatostatin, tachykinin-1, and 5 other genes in colon cancer.	16952549	Gastroenterology
A multigene expression panel for the molecular diagnosis of Barrett's esophagus and Barrett's adenocarcinoma of the esophagus.	15107828	Oncogene
A new specific gene expression in squamous cell carcinoma of the esophagus detected using representational difference analysis and cDNA microarray.	16446548	Oncology
Aberrant methylation of Reprimo in human malignancies.	15700311	Int J Cancer
Aberrant methylation of the CDH13 (H-cadherin) promoter region in colorectal cancers and adenomas.	12067979	Cancer Res
Aberrant promoter methylation of multiple genes during multistep pathogenesis of colorectal cancers.	16108009	Int J Cancer
Activation of the esophagin promoter during esophageal epithelial cell differentiation.	12036303	Genomics
Activin type II receptor restoration in ACVR2-deficient colon cancer cells induces transforming growth factor-beta response pathway genes.	15520171	Cancer Res
An ultrasensitive new DNA microarray chip provides gene expression profiles for preoperative esophageal cancer biopsies without RNA amplification.	18511875	Oncology
An unsupervised approach to identify molecular phenotypic components influencing breast cancer features.	14996713	Cancer Res
Analysis of genetic and epigenetic alterations of the PTEN gene in gastric cancer.	11964046	Virchows Arch
Application of cDNA microarrays to generate a molecular taxonomy capable of distinguishing between colon cancer and normal colon.	12101425	Oncogene
Artificial neural networks and gene filtering distinguish between global gene expression profiles of Barrett's esophagus and esophageal cancer.	12067993	Cancer Res
Artificial neural networks distinguish among subtypes of neoplastic colorectal lesions.	11874992	Gastroenterology
Beyond Field Effect: Analysis of Shrunken Centroids in Normal Esophageal Epithelia Detects Concomitant Esophageal Adenocarcinoma.	18425214	Bioinform Biol Insights
Esophagin and proliferating cell nuclear antigen (PCNA) are biomarkers of human esophageal neoplastic progression.	15221970	Int J Cancer
Genome-wide methylation analysis shows similar patterns in Barrett's esophagus and esophageal adenocarcinoma.	23996928	Carcinogenesis
Global gene expression profiling in Barrett's esophagus and esophageal cancer: a comparative analysis using cDNA microarrays.	11821959	Oncogene
HNPCC-associated small bowel cancer: clinical and molecular characteristics.	15765394	Gastroenterology
Hypermethylation of tachykinin-1 is a potential biomarker in human esophageal cancer.	17975140	Clin Cancer Res
Hypermethylation of the AKAP12 promoter is a biomarker of Barrett's-associated esophageal neoplastic progression.	18199717	Cancer Epidemiol Biomarkers Prev
Hypermethylation of the hMLH1 gene promoter is associated with microsatellite instability in early human gastric neoplasia.	11313962	Oncogene
Hypermethylation of the nel-like 1 gene is a common and early event and is associated with poor prognosis in early-stage esophageal adenocarcinoma.	17452981	Oncogene
Hypermethylation of the p14(ARF) gene in ulcerative colitis-associated colorectal carcinogenesis.	11861396	Cancer Res
Identification of genes uniquely involved in frequent microsatellite instability colon carcinogenesis by expression profiling combined with epigenetic scanning.	15059896	Cancer Res
Inactivation of p16, RUNX3, and HPP1 occurs early in Barrett's-associated neoplastic progression and predicts progression risk.	15824739	Oncogene
Instabilotyping reveals unique mutational spectra in microsatellite-unstable gastric cancers.	12097267	Cancer Res
Instabilotyping: comprehensive identification of frameshift mutations caused by coding region microsatellite instability.	11507051	Cancer Res
Loss of heterozygosity and mutational analyses of the ACTRII gene locus in human colorectal tumors.	14691305	Lab Invest
Molecular phenotype of inflammatory bowel disease-associated neoplasms with microsatellite instability.	16012936	Gastroenterology
Mutational and LOH analyses of the chromosome 4q region in esophageal adenocarcinoma.	16837775	Oncology
Novel decapeptides that bind avidly and deliver radioisotope to colon cancer cells.	17912343	PLoS One
Polo-like kinase and survivin are esophageal tumor-specific promoters.	16487489	Biochem Biophys Res Commun
Prediction of lymph node metastasis with use of artificial neural networks based on gene expression profiles in esophageal squamous cell carcinoma.	15545505	Ann Surg Oncol
Prediction of survival in patients with esophageal carcinoma using artificial neural networks.	15751017	Cancer
Promoter hypermethylation of CDH13 is a common, early event in human esophageal adenocarcinogenesis and correlates with clinical risk factors.	18729198	Int J Cancer
Promoter methylation and response to chemotherapy and radiation in esophageal cancer.	16678495	Clin Gastroenterol Hepatol
Promoter methylation regulates cyclooxygenase expression in breast cancer.	15217498	Breast Cancer Res
RAB32 hypermethylation and microsatellite instability in gastric and endometrial adenocarcinomas.	16557577	Int J Cancer
Rare CpG island methylator phenotype in ulcerative colitis-associated neoplasias.	17408633	Gastroenterology
Rarity of Somatic Mutation and Frequency of Normal Sequence Variation Detected in Sporadic Colon Adenocarcinoma Using High-Throughput cDNA Sequencing.	18389087	Bioinform Biol Insights
Reprimo methylation is a potential biomarker of Barrett's-Associated esophageal neoplastic progression.	17121882	Clin Cancer Res
Sparse logistic regression with Lp penalty for biomarker identification.	17402921	Stat Appl Genet Mol Biol
Spermine oxidation induced by Helicobacter pylori results in apoptosis and DNA damage: implications for gastric carcinogenesis.	15574757	Cancer Res
Thapsigargin resistance in human prostate cancer cells.	16770788	Cancer
The molecular signature of normal squamous esophageal epithelium identifies the presence of a field effect and can discriminate between patients with Barrett's esophagus and patients with Barrett's-associated adenocarcinoma.	16172218	Cancer Epidemiol Biomarkers Prev
Three-tiered risk stratification model to predict progression in Barrett's esophagus using epigenetic and clinical features.	18382671	PLoS One
Transcriptional profiling suggests that Barrett's metaplasia is an early intermediate stage in esophageal adenocarcinogenesis.	16449976	Oncogene
Transcriptional responses of intestinal epithelial cells to infection with Vibrio cholerae.	15213169	Infect Immun

Interests

Gastrointestinal cancer

The molecular basis of gastrointestinal cancer, including coding region targets of MSI, novel methylation targets, global gene expression profiling, changes in gene copy number, loss of heterozygosity, novel mutational searches, and bioinformatics.

To update protocols, publications, biomarkers, or science data, please contact the Data Management and Coordinating Center.

Site

Johns Hopkins University

Degree(s)

M.D.

Email

smeltzer@jhmi.edu

Fax

410-502-3109

Person ID

1010

EDRN Title

EDRN Associate Member

Note

To update contact information, please visit the Data Management and Coordinating Center .