Open Protocols

Protocol Name	Investigatory Role	Biomarkers	Data Collections
NYU Lung Cancer Biomarker Center	Leading	2	0
Validation of Molecular Biomarkers for the Early Detection of Lung Cancer in the setting of Indeterminate Pulmonary Nodules (Lung Team Project #2)	Involved	15	1

Closed Protocols

Protocol Name	Investigatory Role	Biomarkers	Data Collections
Biomarkers to Distinguish Aggressive Cancers from Non-aggressive or Non- progressing cancers	Leading	17	0
EDRN Resource Network Exchange	Involved	0	0
Soluble Mesothelin Related Peptide (SMRP) and Osteopontin (OPN) as Early Detection Markers for Malignant Mesothelioma (MM)	Involved	4	0
Standard Specimen Reference Set: Lung	Involved	0	0

Publications

Publication Name	PubMed ID	Journal
4-aminobiphenyl is a major etiological agent of human bladder cancer: evidence from its DNA binding spectrum in human p53 gene.	12376482	Carcinogenesis
Chromium(VI) exposure enhances polycyclic aromatic hydrocarbon-DNA binding at the p53 gene in human lung cells.	12727806	Carcinogenesis
Cigarette smoke induces methylation of the tumor suppressor gene NISCH.	23503203	Epigenetics
Clinical correlation of asbestos bodies in BAL fluid.	15364780	Chest
CT scan screening for lung cancer: risk factors for nodules and malignancy in a high-risk urban cohort.	22768300	PLoS One
Detection of lung cancer using weighted digital analysis of breath biomarkers.	18420034	Clin Chim Acta
Distinctive serum protein profiles involving abundant proteins in lung cancer patients based upon antibody microarray analysis.	16117833	BMC Cancer
Effect of CpG methylation at different sequence context on acrolein- and BPDE-DNA binding and mutagenesis.	23042304	Carcinogenesis
Functional genomics in lung cancer and biomarker detection.	12878582	Am J Respir Cell Mol Biol
Gender and lung cancer.	15217534	Clin Lung Cancer
Gene expression profiles in peripheral blood mononuclear cells can distinguish patients with non-small cell lung cancer from patients with nonmalignant lung disease.	19951989	Cancer Res
Glucocorticoids inhibit lung cancer cell growth through both the extracellular signal-related kinase pathway and cell cycle regulators.	12204894	Am J Respir Cell Mol Biol
Identification of an autoantibody panel to separate lung cancer from smokers and nonsmokers.	20504322	BMC Cancer
Impact of a computer-aided detection (CAD) system integrated into a picture archiving and communication system (PACS) on reader sensitivity and efficiency for the detection of lung nodules in thoracic CT exams.	22710985	J Digit Imaging
In vitro mechanisms of lovastatin on lung cancer cell lines as a potential chemopreventive agent.	18034278	Lung
Longitudinal multistage model for lung cancer incidence, mortality, and CT detected indolent and aggressive cancers.	22705252	Math Biosci
Molecular analysis of plasma DNA for the early detection of lung cancer by quantitative methylation-specific PCR.	20592015	Clin Cancer Res
Molecular and genetic aspects of lung cancer.	10764334	Am J Respir Crit Care Med
Mutational spectrum and genotoxicity of the major lipid peroxidation product, trans-4-hydroxy-2-nonenal, induced DNA adducts in nucleotide excision repair-proficient and -deficient human cells.	12820894	Biochemistry
N-hydroxy-4-aminobiphenyl-DNA binding in human p53 gene: sequence preference and the effect of C5 cytosine methylation.	12009904	Biochemistry
Optical detection of buccal epithelial nanoarchitectural alterations in patients harboring lung cancer: implications for screening.	20924114	Cancer Res
Performance of mitochondrial DNA mutations detecting early stage cancer.	18834532	BMC Cancer
Prediction of lung cancer using volatile biomarkers in breath.	17522431	Cancer Biomark
Preferential carcinogen-DNA adduct formation at codons 12 and 14 in the human K-ras gene and their possible mechanisms.	12924950	Biochemistry
Preferential DNA damage and poor repair determine ras gene mutational hotspot in human cancer.	12381705	J Natl Cancer Inst
Resection of non-small cell lung cancers reverses tumor-induced gene expression changes in the peripheral immune system.	21807633	Clin Cancer Res
S-adenosylmethionine as a biomarker for the early detection of lung cancer.	17934114	Chest
Selective p38 activation in human non-small cell lung cancer.	11970907	Am J Respir Cell Mol Biol
Sequence specificity of Cr(III)-DNA adduct formation in the p53 gene: NGG sequences are preferential adduct-forming sites.	16251206	Carcinogenesis
Sputum-based molecular biomarkers for the early detection of lung cancer: limitations and promise.	24212941	Cancers (Basel)
Standard operating procedures for serum and plasma collection: early detection research network consensus statement standard operating procedure integration working group.	19072545	J Proteome Res
Unlocking biomarker discovery: large scale application of aptamer proteomic technology for early detection of lung cancer.	21170350	PLoS One
Variant Ciz1 is a circulating biomarker for early-stage lung cancer.	23074256	Proc Natl Acad Sci U S A

Interests

Genetic profile of preneoplastic lesions

Genetic profile of preneoplastic lesions and alteration of the profile with inhaled corticosteroids.

Lung Cancer

Early detection biomarkers

To update protocols, publications, biomarkers, or science data, please contact the Data Management and Coordinating Center.

Site

New York University School of Medicine

Degree(s)

M.D., M.P.H

Email

william.rom@nyumc.org

Fax

(212) 263-8442

Person ID

1012

EDRN Title

EDRN Associate Member

Note

To update contact information, please visit the Data Management and Coordinating Center .