Abbreviated Name

BDL Esophageal Biomarker Development

Lead Investigator

Markowitz, Sanford — Case Western Reserve University

Coordinating Investigator

No coordinating investigator

Involved Investigators

• Markowitz, Sanford — Case Western Reserve University

Abstract

Prospective enrollment of individuals referred for upper endoscopy who will undergo comparison esophageal sampling with an esophageal balloon device and analysis of methylated DNA biomarkers for detection of Barrett’s esophagus.

Aims

Evaluation of methylated DNA for detection of Barrett’s esophagus on samples retrieved by an esophageal balloon

Analytic Method

No analytic method available.

Publications

• Aberrant vimentin methylation is characteristic of upper gastrointestinal pathologies.
• Identifying DNA methylation biomarkers for non-endoscopic detection of Barrett's esophagus.

Biomarkers

• EsoGuard

Data Collections

• Esocheck esophageal balloon collection
• Esophageal Adenocarcinoma Cross Sectional Study

 Team Project

Start Date

Jan 1 2011

Protocol ID

488

Protocol Type

Single

Fields of Research

• Epigenomics

Collaborative Group

G.I. and Other Associated Cancers Research Group

Cancer Types

• Malignant neoplasm of colon