The UBA1-STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade.
Abstract
Our study reveals UBA1 as a predictive biomarker for clinical outcomes in ICB cohorts, mediating cancer immune evasion and ICB resistance. We further highlight JAK1 stabilization as a key mechanism of UBA1 inhibition and nominate the UBA1-STUB1 axis as an immuno-oncology therapeutic target to improve the efficacy of ICB.
EDRN PI Authors
Medline Author List
- Bao Y
- Cao X
- Chinnaiyan AM
- Choi JE
- Chu A
- Cieslik M
- Cruz G
- Gondal M
- Hosseini N
- Hu J
- Kang S
- Kryczek I
- Lin H
- Mahapatra S
- Mannan R
- Miner SJ
- Qiao Y
- Robinson DR
- Shahine M
- Su F
- Vaishampayan U
- Wang R
- Wu YM
- Yang F
- Yu J
- Zhang Y
- Zheng Y
- Zou W